Kaposi’s sarcoma herpesvirus (KSHV/HHV8) is a human oncogenic virus and, like all herpesviruses, establishes a lifelong infection in the host. Herpesvirus infection is divided into two phases: lytic (active) and latent (dormant). Viral reactivation, the shift from latency to an active lytic phase, occurs over the course of infection. Lytic reactivation in a KSHV-infected individual is necessary for persistent viral infection, disease and oncogenesis. This project will examine the impact of environmental chemicals and stressors, such as alcohol exposure, on KSHV reactivation.