Ricardo M Richardson
Dr. Richardson is a professor of Biology and the director of the Cancer Research Program, JLC-BBRI, at North Carolina Central University in Durham, N.C. He served on the faculty of Duke University Medical Center for ten years and then moved to Meharry Medical College, Nashville, T.N., where he became the Henry A. Moses Associate Professor of Biochemistry for two years. Dr. Richardson earned his B.S., M.S., and Ph.D. in biology from the Universitat Autonoma of Barcelona, Spain, and had postdoctoral training in Dr. Marlene Hosey's laboratory at Northwestern University, Chicago, I.L.
Dr. Richardson's current research interest is on chemoattractant and chemokine receptors. He has authored more than 60 research articles, reviews, and book chapters and has been invited to give lectures in many research institutions. As the director of the JLC-BBRI Cancer Research Program in partnership with the UNC Lineberger Comprehensive Cancer Center and Duke University Comprehensive Cancer Center, Dr. Richardson supervises a team of principal investigators focusing on prostate, breast, oral, esophagus, ovarian, and lung cancer, as well as community outreach and student training.
Publications
Richardson, RM, Pridgen, BC, Haribabu, B., and Snyderman, R. Regulation of the human chemokine receptor CCR1: cross-regulation by CXCR1 and CXCR2. (2000) J Biol Chem. 275, 9201-9208. PMID: 10734056.
Richardson, R. M., Marjoram, R.J., Barr, A., and Snyderman, R. (2001) Inhibition of the PAF receptor by RGS4 Requires the Receptor’s Cytoplasmic Tail. Biochemistry, 40: 3583-3588. PMID: 11297424
Fong, AM., Premont, R, Richardson, RM, Yu, AM, Lefkowitz, RJ., and Patel D. (2002). Defective lymphocyte chemotaxis in β-arrestin2 and GRK6-deficient mice. PNAS. 99, 7478-7483. PMID: 12032308
Richardson, R. M., Marjoram, R. J., Barak, L., and Snyderman R. Role of the Carboxyl-terminus of CXCR1 and CXCR2 on IL-8-mediated Leukocyte functions. (2003), J. Immunol., 70, 2904-2911. PMID: 12626541
Richardson, R. M., Tokunaga, K, Marjoram, M.J., Sata, T., and Snyderman R. Interleukin-8 mediated heterologous receptor internalization provides resistance to HIV-1 infection: Role of signal strength and receptor desensitization. (2003). J. Biol. Chem., 278, 15867-15873. PMID: 12594210.
Miyazaki, D., Nakamura, T, Toda, M., Cheung-Chau, K-W., Richardson, R. M. and Ono, S. J. Co-stimulation of mast cells via CCR1 required for mast cell degranulation and allergic responses in vivo. (2005) J. Clinical Investigation 115:434-442. PMID: 15650768
Nasser, M. W., Marjoram, R. J., Raghuwanshi, S. K., Brown, S., and Richardson, R. M. Protein Kinase C-epsilon mediates cross-desensitization among CXCR1, CXCR2 and CCR5. (2005) J. Immunol., 174 6927-6933. PMID: 15905535.
Su, Y., Raghuwanshi, S. K., Yu, Y, Nanney L. B. Richardson R. M and Richmond A. β-arrestin-2 knockout promotes neovascularization and re-epithelialization in mouse excisional wounds (2005) J. Immunol., 175 5396-5402. PMID: 16210646.
Brown, S. L., Jala, V. R., Raghuwanshi, S. K., Nasser, M. W., Haribabu, B. and Richardson, R. M. Activation and regulation of platelet-activating factor receptor: role of Gi and Gq in receptor-mediated chemotactic, cytotoxic and cross-regulatory signals (2006) J. Immunol., 177: 3242 – 3249. PMID: 16920964
Nasser M. W., Raghuwanshi S. K., Malloy, K. M., Shim, J., Rajarathnam K., and Richardson, R. M. CXCR1 and CXCR2 activation and regulation: Role of aspartate 199 of the second extracellular loop of CXCR2 in CXCL8-mediated rapid receptor internalization. (2007) J. Biol. Chem 282: 6906 – 6915. PMID: 17204468
Raghuwanshi S. K., Nasser M. W., Malloy K. M., Chen, X L., Strieter, R. M., and Richardson, R. M. βarrestin-2 modulates tumor development, invasion and metastasis: Distinct role of CXCR2 and NF-κB. (2008). J. Immunol., 180:5699-5706. PMID: 18390755
Nasser MW, Raghuwanshi SK, Grant DJ, Jala VR, Rajarathnam K, Richardson RM. (2009) Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer. J Immunol. 183:3425-32. PMID: 19667085
Toda, M., Kuo, CH., Borman, SK., Richardson, RM., Inoko, A., Inagaki, M., Schneider, K., Ono, SJ. Evidence That Formation of Vimentin·Mitogen-activated Protein Kinase Complex Mediates Mast Cell Activation following FcϵRI/CC Chemokine Receptor 1 Cross-talk. (2012). J. Biol. Chem. 287: 24516-24524 PMID:22613718
Grant DJ, Hoyo C, Oliver SD, Gerber L, Shuler K, Calloway E, Gaines AR, McPhail M, Livingston JN, Richardson RM, Schildkraut JM, Freedland SJ. Association of Uridine DiphosphateGlucuronosyltransferase 2B Gene Variants with Serum Glucuronide Levels and Prostate Cancer Risk. (2012). Genet Test Mol Biomarkers. (2012) PMID:2309824
Raghuwanshi SK, Su Y, Singh V, Haynes K, Richmond A, Richardson RM. The chemokine receptors CXCR1 and CXCR2 couple to distinct G-protein-coupled receptor kinases to mediate and regulate leukocyte functions. (2012) J. Immunol. 15;189(6):2824-32. PMID:22869904
Raghuwanshi SK, Smith N, Rivers EJ,Thomas AJ, Sutton N, Hu Y; Mukhopadhyay S, Chen, XL, Leung T, and Richardson RM. GRK6 deficiency promotes angiogenesis, tumor progression and metastasis (2013) J. Immunol. 190:5329-5336 PMID:
Singh V, Raghuwanshi SK, Smith K, Rivers EJ, and Richardson MR. G-protein-coupled receptor kinase-6 interacts with Activator of G-protein signaling-3 to regulate CXCR2-mediated cellular functions (2013) J. Immunol.
Joseph PRB, Poluri KM, Gangavarapu P, Rajagopalan L, Raghuwanshi S, Richardson RM, Garofalo RP and Rajarathnam, Proline K. Mutagenesis as a Strategy for Design of Monomeric Proteins (2013) Biophysical Journal.