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Epigenetic Regulation by UDP-Glucuronosyltransferases

Several lines of recent evidence suggest that the steroideogenic enzymes responsible for the catabolism of intraprostatic testosterone metabolites are important to biochemical recurrence and progression to castration-resistant prostate cancer (CRPC). The regulation of the expression of UGT2B enzymes is critical for the normal hormonal microenvironment in prostate and other tissues. Previous studies have shown that UGT2B15 is negatively regulate in prostate cancer metastases and CRPC tumors suggesting that loss of expression may be important for prostate tumor progression. For this proposed study preliminary evidence shows that UGT2B15 is expressed in nuclear and chromatin protein fractions of the LNCaP prostate cancer cell line. The results from this study will help elucidate the mechanism by which hormone perturbations occur that lead to prostate cancer progression in CRPC. 

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