For men over 40, prostate cancer is the most frequently diagnosed form of cancer and the second leading cause of death. African American (AA) men are particularly affected. The Incidence rate of prostate cancer and transition to the most aggressive forms of the disease are much higher in AA men in comparison to Caucasian or Asian men of the same age group; as a result prostate cancer mortality among AAs is more than twice that of European American men. At JLC-BBRI, Drs. Delores Grant, K Sean Kimbro, Somnath Mukhopadhyay and Ricardo Richardson are studying the role of alterations in gonadotropic hormones, endocannabinergic bioactive lipid mediators and innate immune signaling pathways in the regulation of prostate cancer in AA men.