Nutritious diets reduce the risk of chronic disease because foods and medicinal herbs contain bioactive constituents. The JLC-BBRI Nutrition Research Program at the North Carolina Research Campus in Kannapolis uses metabolomic and nutrigenomic approaches to identify and evaluate natural products for disease prevention and treatment.
We use zebrafish to:
Understand the molecular mechanisms of disease
Validate therapeutic compounds such as drug-like small molecules and natural products.
We are currently:
Studying the preventive effects of bioactive food/herb compounds on cancer, diabetes and other cardio-metabolic diseases
Applying metabolomics to identify dietary exposure markers in monitoring and modifying personal nutrition
Purifying natural products from foods and medicinal herbs (as in traditional Chinese medicine) and analyzing their structure, bioavailability and biotransformation
Dissecting the molecular mechanisms of blood vessel development using chemical and genetic approaches to identify new targets suitable for disease treatments