North Carolina Central University
1801 Fayetteville St.
Durham, NC 27707
Human cancer has a multifactorial etiology, with genetic, biological, physical, and/or chemical agents involved in triggering disease. Qualitative and/or quantitative changes occur in genes that alter the regulation of cell growth, differentiation, and proliferation leading to transformation. The JLC-BBRI toxicology/carcinogenesis program explores the causes of cancer and its prevention, using molecular and genetic strategies 1) to define the critical steps in carcinogenesis and 2) to understand the interplay between genes and the environment. Studies also include single nucleotide polymorphism analysis of genes contributing to racial, ethnic, and gender disparities. Studies of breast, ovarian, lung, esophageal, pancreatic and prostate cancers are currently underway. Areas of expertise include biomarkers of disease; genetic polymorphisms; cause and prevention; contributions of innate immunity to transformation; and susceptibility to disease.