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BBRI/Bowles Center for Alcohol Studies (CAS) Cooperative Agreement

The National Institute for Alcohol and Abuse and Alcoholism (NIAAA) has funded a U54 cooperative agreement between faculties of the Biomedical/Biotechnology Research Institute (BBRI) at North Carolina Central University (NCCU) and the Bowles Center for Alcohol Studies (CAS) at The University of North Carolina (UNC) School of Medicine entitled “Mechanisms of Alcoholic Pathology”. The objectives of this U54 Collaborative Minority Alcohol Research Center Development (CMARCD) partnership are:

  • To investigate molecular mechanisms of alcohol-induced cellular pathology. By conducting an integrated and focused investigation into the molecular mechanisms of alcohol pathology this proposal will make important contributions to understanding alcohol morbidity and will create an active and successful research program in alcohol pathology at NCCU. Current BBRI investigator projects include “Oxidative stress in alcohol-associated oral carcinogenesis” (Xiaoxin “Luke” Chen); “Mechanisms and pathogenesis of ethanol-induced CNS abnormalities in zebrafish” (Greg Cole); and “Ethanol-cannabinoid interaction in the regulation of neurogenesis” (Somnath Mukhopadhyay).
  • To provide scholarly education concerning alcohol pathology. NCCU students will study alcohol pharmacology and alcohol related pathologies and health disparities through an Annual Alcohol Research Day; new alcohol course curricula developed by NCCU faculty; a new alcohol seminar series to be hosted by BBRI; continuation of the existing UNC Bowles Center for Alcohol Studies seminar series; and NCCU student fellowships in minority alcohol pathology.

Ultimately, this grant will conduct, promote, support, and mentor research focused on mechanisms of alcohol pathology, thus creating an active and successful alcohol research program within BBRI that synergizes with UNC’s CAS to advance education and discovery.

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